Detalhe da pesquisa
1.
Phase 1 study of the ATR inhibitor berzosertib in combination with cisplatin in patients with advanced solid tumours.
Br J Cancer
; 125(4): 520-527, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34040174
2.
Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours.
Br J Cancer
; 125(4): 510-519, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34040175
3.
Nanoliposome targeting in breast cancer is influenced by the tumor microenvironment.
Nanomedicine
; 17: 71-81, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30654182
4.
Safety and pharmacokinetics of MM-302, a HER2-targeted antibody-liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation study.
Br J Cancer
; 119(9): 1086-1093, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30361524
5.
Liposomal Irinotecan Achieves Significant Survival and Tumor Burden Control in a Triple Negative Breast Cancer Model of Spontaneous Metastasis.
Mol Pharm
; 15(9): 4132-4138, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30059232
6.
Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier (BTB), and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer.
Pharm Res
; 35(2): 31, 2018 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29368289
7.
Extended topoisomerase 1 inhibition through liposomal irinotecan results in improved efficacy over topotecan and irinotecan in models of small-cell lung cancer.
Anticancer Drugs
; 28(10): 1086-1096, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28857767
8.
A gradient-loadable (64)Cu-chelator for quantifying tumor deposition kinetics of nanoliposomal therapeutics by positron emission tomography.
Nanomedicine
; 11(1): 155-65, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25200610
9.
Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients.
Am J Pathol
; 183(5): 1446-1460, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24035511
10.
Exploratory Food Effect Assessment in Patients in Early Clinical Development of Oncology Drugs.
Clin Pharmacol Ther
; 114(2): 288-302, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37078098
11.
HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity.
Toxicol Appl Pharmacol
; 262(1): 1-10, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22676972
12.
DataPflex: a MATLAB-based tool for the manipulation and visualization of multidimensional datasets.
Bioinformatics
; 26(3): 432-3, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19965880
13.
Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types.
Cancer Chemother Pharmacol
; 87(2): 185-196, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33145616
14.
Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia.
Mol Imaging Biol
; 22(3): 653-664, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31482415
15.
Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.
Toxicol Appl Pharmacol
; 237(3): 317-30, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19362101
16.
Multiple effects of acetaminophen and p38 inhibitors: towards pathway toxicology.
FEBS Lett
; 582(8): 1276-82, 2008 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18282474
17.
Analysis of mechanistic pathway models in drug discovery: p38 pathway.
Biotechnol Prog
; 24(1): 96-109, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-17918858
18.
Companion Diagnostic 64Cu-Liposome Positron Emission Tomography Enables Characterization of Drug Delivery to Tumors and Predicts Response to Cancer Nanomedicines.
Theranostics
; 8(9): 2300-2312, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29721081
19.
Essential (and Largely Untaught) Skills for Clinical Pharmacology in Oncology Drug Development.
Clin Pharmacol Ther
; 111(2): 354-357, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33971015
20.
Liposomal 64Cu-PET Imaging of Anti-VEGF Drug Effects on Liposomal Delivery to Colon Cancer Xenografts.
Theranostics
; 7(17): 4229-4239, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29158822